Welcome to Our Academy
The Academy of Oxidative Stress Disorders is focused on hosting convenient peer reviewed CME platforms and conferences to educate and connect health care professionals with emerging treatment protocols to manage oxidative stress related diseases.
This is all done by modulating the nitro-redox sensitive biochemical and epigenetic pathways.
As clinicians and scientists, we have come to understand that the Redox potential controls the electrochemical environment at the cellular level, while impacting fundamental biochemical mechanisms throughout the body.
Mitochondrial function, cellular signaling, cellular proliferation, differentiation and apoptosis, immune-modulation, cancer growth, cardiac rhythm and circadian rhythm, neuroplasticity, sympathetic tone, enzymatic function, receptor function, endothelial function, gene expression and telomere length are all examples of Redox mediated processes supported in peer reviewed literature.
In the mid-1980s, advancements in medical science began to unravel the profound significance of redox biology and its role in human health. Since that time, at least 211,000 scientific studies related to the topic appear in Pub Med.
Reactive oxygen species (ROS) are necessary participants in normal biochemical functions but can induce pathology when imbalanced. The endogenous production of ROS during normal signaling is essential for cellular regeneration and healing effects. However, excessive ROS production and accumulation leads to detrimental processes that cause degeneration and cellular injury. Oxidative stress related disease occurs when antioxidant defenses cannot balance the production of ROS.
Our bodies antioxidant defense mechanisms represent an active process fulfilled by metabolic energy systems, antioxidant enzymes and epigenetics, in addition to the roles of more well-known small molecule antioxidants and related detox compounds.
Interestingly, Redox manipulation can improve homeostasis and cellular health, but it can also be used as a clinical tool. We are just now seeing revolutionary new therapies being developed from this concept.
The age-dependent Nitro-redox imbalance is closely related to oxidative stress and the various syndromes associated with “aging”. ROS overproduction is involved in diverse oxidative stress related diseases such as degenerative, autoimmune, metabolic, chronic inflammatory, chronic infectious, and psychological diseases, plus cancers, aging, pain and many more.
In order to develop effective therapeutic approaches against oxidative stress related diseases, it is important to identify the mechanisms underlying the initial pathological events. Targeted antioxidant treatments could be a promising therapeutic approach. However, the complex nature of oxidative stress related diseases and failure of monotherapies suggest that an antioxidant therapy should be accompanied by additional targeted therapeutic interventions to enhance the restoration of the Nitro-redox balance.
The Academy welcomes all disciplines of interested clinicians, healthcare providers, researchers and scientists including chemistry, biochemistry, cellular biology, physiology, pathology, pharmacology and all specialties of Medicine.